Thailanstatin A CAS 1426953-21-0

Deskrizzjoni tal-prodott:

Isem tal-Prodott: Thailanstatin A CAS NO: 1426953-21-0

Sinonimi:

(3R,5S,7R,8R)-7-{(1E,3E)-5-(2S,3S,5R,6R)-5-{(2Z,4S)-4-(acetyloxy)pent -2-enoylamino}-3,6-dimethyltetrahydro-2H-pyran-2-yl-3-methylpenta-1,3-dien-1-yl}-8-hydroxy-1,6-dioxaspiro2.5oct-5-ilaċetiku aċidu;

1,6-Dioxaspiro2.5octane-5-aceticacid,7-(1E,3E)-5-(2S,3S,5R,6R)-5-(2Z,4S) )-4-(acetyloxy)-1-oxo-2-penten-1-ylaminotetrahydro-3,6-dimethyl-2H-pyran-2-yl-3-methyl-1,3-pentadien-1-yl-8- idrossi-, (3R,5S,7R,8R)-;

Proprjetajiet Fiżiċi Kimiċi:

Dehra: Trab solidu

Assaġġ : Akbar minn jew ugwali għal 99.0 fil-mija

Thailanstatin A, kompost ewlieni promettenti għall-iskoperta tad-droga u l-isforzi ta 'żvilupp, huwa derivat minn Thailandensis burkholderia MSMB43. Tiżvela ċitotossiċità nanomolari sa subnanomolari baxxa kontra varjetà ta 'linji ta' ċelluli tal-kanċer tal-bniedem.

Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding "linker-less" ADC.

Jekk inti interessat fil-prodotti tagħna jew għandek xi mistoqsijiet, jekk jogħġbok tħossok liberu li tikkuntattjana!

Prodotti taħt privattiva huma offruti għall-iskop RD biss. Madankollu, ir-responsabbiltà finali hija esklussivament tax-xerrej.

It-tags Popolari: thailanstatin a cas 1426953-21-0, manifatturi, fornituri, fabbrika, jixtru, fl-istokk

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