7-Xylosyl-10-deacetyltaxol CAS 90332-63-1

Deskrizzjoni tal-prodott

Isem tal-Prodott: 7-Xylosyl-10-deacetyltaxol CAS 90332-63-1

Sinonimi:

Aċidu benżepropanoiku, β- (benzoylamino) -α-hydroxy-, (2aR, 4S, 4aS, 6R, 9S, 11S, 12S, 12aR, 12bS) -12b- (aċetiloxi) -12- (benzoyloxy) -2a, 3, 4,4a, 5,6,9,10,11,12,12a, 12b-dodecahydro-6,11-dihydroxy-4a, 8,13,13-t etramethyl-5-oxo-4- (β-D- xylopyranosyloxy) -7,11-methano-1H-cyclodeca [3,4] benz [1,2-b] oxet-9-yl ester, (αR, βS) -;

(2α, 3β, 5β, 7β, 10β, 13α) -4-Acetoxy-13 - {[(2R, 3S) -3- (benzoylamino) -2-hydroxy-3-phenylpropanoyl] oxy} -1,10-dihydroxy -9-oxo-7- (β-D-xylopyranosyloxy) -5,20-epoxytax-11-en-2-yl benzoate;

(2α, 5β, 7β, 10β, 13α) -4-Acetoxy-13 - {[(2R, 3S) -3- (benzoylamino) -2-hydroxy-3-phenylpropanoyl] oxy} -1,10-dihydroxy-9 -oxo-7- (β-D-xylopyranosyloxy) -5,20-epoxytax-11-en-2-yl benzoate;

Aċidu benżepropanoiku, β- (benzoylamino) -α-hydroxy-, (2aR, 4S, 4aS, 6R, 9S, 11S, 12S, 12aS, 12bS) -12b- (aċetiloxi) -12- (benzoyloxy) -2a, 3, 4,4a, 5,6,9,10,11,12,12a, 12b-dodecahydro-6,11-dihydroxy-4a, 8,13,13-t etramethyl-5-oxo-4- (β-D- xylopyranosyloxy) -7,11-methano-1H-cyclodeca [3,4] benz [1,2-b] oxet-9-yl ester, (αR, βS) -

10-Deacetyl-7-xylosyl paclitaxel;

Propjetajiet Kimiċi u Fiżiċi

Id-dehra: trab abjad

Ħlas: ≥99.0%,

Densità: 1.5 ± 0.1 g / cm3

Punt tat-togħlija: 1068.4 ± 65.0 ℃ fi 760 mmHg

Punt tal-flash: 599.9 ± 34.3 ℃

PSA: 274.14000

LogP: 7.18

Pressjoni tal-fwar: 0.0 ± 0.3 mmHg f'25 ° C

Indiċi ta 'Refrazzjoni: 1.660

Solubbli fil-metanol, etanol, DMSO u solventi organiċi oħra.

10-Deacetyl-7-xylosyl paclitaxel huwa derivat ta 'Paclitaxel b'karatteristiċi farmakoloġiċi mtejba u solubilità ogħla fl-ilma. Valur ICIC: Mira: Microtubule inhibitor10-Deacetyl-7-xylosyl paclitaxel indotta b'ċitazzjoni taċ-ċellula mitotika u apoptożi kif imkejjel permezz ta' ċitometrija tal-fluss, ħxuna tad-DNA , u mikroskopija elettronika ta 'trasmissjoni. L-espressjoni ta 'Pro-apoptotic Bax u Bad proteina kienet regolata u espressa anti-apoptotika Bcl-2 u Bcl-XL regolata fl-isfel, li twassal għal disturbi fil-permeabilità tal-membrana mitokondrijali u għall-attivazzjoni ta' caspase-9. Imbagħad, il-caspase-9 attivat caspases down-3 u -6, iżda mhux caspase-8. L-offerta ġiet attivata wkoll minn caspase-3. Bil-maqlub, trattament b'inibitur speċifiku ta 'caspase-10 ma jistax jipproteġi ċ-ċelloli PC-3 minn apoptożi kkawżata minn 7-xylosyl-10-deacetyl-paclitaxel. Barra minn hekk, 7-xylosyl-10-deacetylpaclitaxel ma kellu l-ebda effett fuq l-espressjoni tal-proteini CD95 u NF-kappaB, li jindika li l-apoptożi ġiet indotta mill-passaġġ dipendenti mitokondrijali fiċ-ċelloli PC-3.

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It-tags Popolari: 7-xylosyl-10-deacetyltaxol cas 90332-63-1, manifatturi, fornituri, fabbrika, jixtru, fl-istokk

• Par ta ' l-: Allopurinol CAS 315-30-0
• Li jmiss: 10-DAT, Deacetyltaxol CAS 78432-77-6